Protein Details: Cation channel sperm-associated protein 2

Protein ID

ICDB_Pro_0026

Protein Name

Cation channel sperm-associated protein 2

Gene Name

Catsper2

Organism

Mus musculus (Mouse)

Length

588 amino acids

AlphaFoldDB

AF-A2ARP9-F1-model_v4.pdb

Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility; a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.

Sequence

MAQEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSIKPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFREYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGSIIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDIIETSDASDDDDDDDDDDDDDDDDDDDKSDATESDNEESDSENSESENSESEKIDPEKDYAKKSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEKVKEESKEKAYPVSHSISSHGSTAADTAFLENLDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMSFEDK

PDB Structures

7EEB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Testis-specific

DOI ID

10.1073/pnas.221454998; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1073/pnas.2136654100; 10.1074/jbc.m501430200; 10.1016/j.ydbio.2006.11.007; 10.1093/molehr/gam009; 10.1038/nature09767; 10.1038/ncomms1153; 10.1016/j.celrep.2021.110226; 10.1038/s41586-021-03742-6